| 9/2/2017 | Northern Iowa (8-5) | 24 | at | Iowa State | 42 | MVC (1AA) | ||
| 9/9/2017 | Iowa (8-5) | 44 | at | Iowa State | 41 | OT | B10 | |
| 9/16/2017 | Iowa State | 41 | at | Akron (7-7) | 14 | at MAC | ||
| 9/28/2017 | Texas (7-6,5-4) | 17 | at | Iowa State | 7 | |||
| 10/7/2017 | Iowa State | 38 | at | Oklahoma (12-2,9-1) | 31 | |||
| 10/14/2017 | Kansas (1-11,0-9) | 0 | at | Iowa State | 45 | |||
| 10/21/2017 | Iowa State | 31 | at | Texas Tech (6-7,3-6) | 13 | |||
| 10/28/2017 | TCU (11-3,7-3) | 7 | at | Iowa State | 14 | |||
| 11/4/2017 | Iowa State | 16 | at | West Virginia (7-6,5-4) | 20 | |||
| 11/11/2017 | Oklahoma State (10-3,6-3) | 49 | at | Iowa State | 42 | |||
| 11/18/2017 | Iowa State | 23 | at | Baylor (1-11,1-8) | 13 | |||
| 11/25/2017 | Iowa State | 19 | at | Kansas State (8-5,5-4) | 20 | |||
| 12/30/2017 | Iowa State | 21 | vs | Memphis (10-3) | 20 | Liberty Bowl (Memphis TN) | vs AAC |
| vs Iowa State | vs Other Opponents | Iowa State compared to OOs | |
| Record: | 5-8 | 91-66 | |
| Points Scored: | 20.92 | 33.63 | 12.71 |
| Points Allowed: | 29.23 | 28.09 | 1.14 |
| Margin: | -8.31 | 5.54 | 13.85 |
| Total Points: | 50.15 | 61.72 | -11.57 |